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Friday, 23 March 2012

I can only describe this piece as "true and heart-wrenching"

Slaves to Science by William Speed Weed


Sally bounds up the stairs two at a time. She fumbles with the key, then bursts into the lab. With fingers still frozen from the morning air, she takes a tray of hockey-puck-size clear plastic cups out of an incubator. The cups contain fish embryos and water. She drops some of the fluid onto a slide and looks through the microscope. There they are, little spheres with dark paisley inlays.

These particular fish are growing without hearts because Sally knocked out a gene fish need to grow hearts. She can now study this missing gene by watching what doesn’t happen in its absence. She had to get the fish out of the incubator at exactly this stage of development — just as the organs are forming, but before these fishlings die when they discover they have no hearts. Having not left the lab until midnight, Sally overslept the 6 a.m. alarm.

Monday, 19 March 2012

Bionic man is not just science fiction

Woman considers hand removal for bionic replacement

Nicola Wilding meets Viennese surgeon Oskar Aszmann for a consultation

Nicola Wilding, 35, lost the use of her right arm in a car crash 12 years ago.
Nerve transplants have returned some movement to her upper arm, but she's been told she'll never be able to use her hand again.

Now, having seen a Newsnight film on the work of Austrian surgeon Oskar Aszmann, she is actively considering having her hand cut off and replaced with a bionic prosthesis.

"Twelve years ago on the motorway coming back from Brighton I had a crash," she says, in the kitchen of the Surrey home she shares with her parents and son.

"In the impact I brought my arm up to protect my head and it's pulled the nerves and the shoulder back. I broke the bones straight across - compound fractures I think here and here," she continues, slicing her good hand across the sites of the breaks.

Nicola sustained severe injuries to the nerves in her shoulder, leaving her arm initially paralysed  
Nicola sustained severe injuries to the nerves in her shoulder, leaving her arm initially paralysed. The bones could be fixed, but the injuries to her brachial plexus, the complex set of nerves which run from the neck via the shoulder to the arm, were always going to prove more problematic.
 
Her entire right arm was left paralysed by the crash, so surgeons performed nerve transplants, taking tissue from her leg and the side of her torso, to try to restore some movement.

Slowly and with the help of physiotherapy, movement returned to her upper arm. But the hand remained paralysed and withered.

"My doctors are like 'That's all we can do for you'," she recalls.
Nicola remained frustrated, and still is.

"It's the everyday things. If you go to butter toast you can't hold it. I've used my teeth to open bottles and chipped some teeth. Taking my clothes off, having a shower. I have to have meals prepared for me - I can't peel a potato as much as I've tried. I'd probably end up injuring myself.

"There are things I just can't do."

Then, last May, she saw a Newsnight film in which Austrian resident Milo underwent elective amputation to have his withered hand replaced with a prosthesis. He had suffered a brachial plexus injury in a motorbike accident, and had also lost the use of his hand.

The film also featured Patrick, the first patient to undergo the procedure, who was already showing off his bionic hand, opening bottles and tying his shoelaces.
The surgeon was Oskar Aszmann.

"I saw the clip of Oskar, and I was just filled with hope, because it could be life changing."

Nicola contacted Mr Aszmann immediately, but it's only this month that she has had the chance to meet him.

The surgeon was giving a lecture on his work to doctors at St Thomas' Hospital, London. Nicola attended the lecture and then met the surgeon for an initial consultation.

In a small room off a hospital ward, Mr Aszmann asked her how she was injured and what treatment she had had. He examined the arm, asking her what she can and cannot feel, and saw what movement she has.

But he was also keen to quiz her on her motivations and her expectations for elective amputation.
Elective amputee Patrick shows what he can do with his bionic hand and tests a new hand with additional wrist movement.

"These are risky decisions - they are irreversible. Once the extremity is gone it's gone, you cannot put it back on again," he says after the meeting, but he believes Nicola is a good candidate.

"She's already ready to go. She says she wants to have a functional hand and arm, so I think for her there's no question in her mind.

"What we have to figure out is what she still needs to qualify for an elective amputation and I think for that she will need to come to Vienna for us to conduct thorough tests."

That will involve testing the electrical output of nerves in her lower arm, to see whether they will provide sufficient signals to steer a bionic hand.
More surgery might be necessary to improve movement in the arm, he says. There may also be surgery he can perform to reduce the persistent pain Nicola suffers in her arm.

Nicola herself seems inspired by the lecture and by her meeting with Mr Aszmann.
"If the possibility is there and I feel that I haven't gone through with that, then I'll feel that I've let myself down.

"I've come this far and this is another door to be opened, so yes, I'm all for it, whatever the outcome, whatever happens, it's all good."

She now has to plan her trip to Vienna, and then, should she be selected for elective amputation, she'll have to think about where she can raise the money, not just for the surgery, but for a lifetime's worth of prosthetic hands and maintenance.

Einstein's Theory of Relativity made easy

Saturday, 17 March 2012

Killer fashion: Does it hurt to look good?

Baila Steinman first noticed the numbness in her leg on a trip to Israel in December. "From the knee to the pelvis, it was numb to the point of being painful," recalls the 52-year-old occupational therapist.

Back home in Brooklyn, a neurologist had her balance on her toes, walk backward on her heels and push back when he put pressure on her legs. Then he asked, "Do you wear tight clothes? Control-top pantyhose? Tight belts?" When she nodded yes, the doctor, Irving Friedman, exclaimed "That's it!"

The culprit: the cinch belts Mrs. Steinman loves to wear. Dr. Friedman said they can compress a major nerve, the lateral, femoral cutaneous nerve, that runs from the abdomen to the outer thigh. He said he frequently sees the condition—called meralgia paresthetica—in policemen who carry guns on their hips and ballet dancers who wear tight tutus. "Anything that puts pressure on that nerve can cause it," he said. "It's very, very common."

Kim Kardashian in tightly cinched belt. Source: Inland Empire Magazine

Mrs. Steinman still wears the belts she loves, just not buckled quite so tight. "I told my friends about this and they cracked up," she says. "I said, 'I'm just letting you girls know, this can happen to you.' "

Apparel and accessories that are too tight, too loose, too heavy, too high or too floppy can all create health issues. Wearers sometimes have no idea that the culprit is their clothes. Of course, modern sartorial trends aren't nearly as punishing as Chinese foot binding or Victorian-era corsets, which could crush women's ribs and displace internal organs.

Here's a look at perhaps what not to wear:


Heidi Klum in skinny jeans. Source: thestyleandbeautydoctor.com

Tight jeans: Squeezing into matchstick jeans with cheese-stick legs cannot only cause nerve compression, it can interfere with digestion, as the Archives of Internal Medicine noted in 1993. Internist Octavio Bessa of Stamford, Conn., wrote that he was seeing 20 to 25 patients a year, usually middle-aged or older men, suffering from abdominal discomfort, distention, heartburn and belching a few hours after eating. "The diagnosis can be made easily in the office by comparing the size of the trousers with the abdominal girth. There is usually a discrepancy of 7.5 centimeters or more," Dr. Bessa wrote, coining the term "tight pants syndrome."
Since then, jean styles have gotten even skinnier and have also been blamed for lower back pain, yeast infections in women and a rare condition called lipoatrophia semicircularis, in which horizontal lesions appear around the thighs.


Body shapers. Source: zimbio.com

Body shapers: Worn too tight or too long, Spanx and other body-tamers can cause both nerve compression and digestive issues—not to mention painful welts where fabric ends and flesh begins. (They're really made for smoothing, not squeezing the wearer down a size.)

Shapers that compress the upper abdomen can also prevent the lungs from fully inflating, reducing oxygen intake, which can lead to lightheadedness. Stomach-flattening "compression wear" for men runs the same risk—and won't really train those abs to stay in place, no matter what the advertising says.

Colin Firth and Matthew Goode from A Single Man in shirts and ties.
Source: famewatcher.com
Shirts and ties: Get headaches, blurred vision or tingling around the ears—particularly at the office? Tight shirt collars and neckties can reduce circulation to the brain and increase intraocular pressure, a risk factor for glaucoma, experts warn. Tight ties can also decrease rangeofmotion in the neck and increase muscle tension in the back and shoulders, according to a study of South Korean office workers in the journal Work last year.
Many men need to loosen up: 67% buy shirts that are smaller than their necks, according to a 1993 study at Cornell University.
And since they tend not to be cleaned as often as other clothing items, neckties can be transmit infection. Some hospitals have sought to ban doctors from wearing them.

Undergarments by Victoria Secrets. Source: wallpaperswide.com

 Undergarments: Lingerie experts say 75% of women wear the wrong size bra. A bra that is too big gives no support, which can cause breast pain and back strain. One that is too tight could presumably cut into the flesh.
Boxers or briefs? Fertility experts advise men who want to become fathers not to spend long periods in tight bike shorts that can raise the temperature of the testes, reducing sperm production.

Fabric and detergent: Allergies to specific fibers are relatively rare, although they occur more often with synthetics and blends than all wool, cotton or silk, according to Apra Sood, a contact dermatitis expert at the Cleveland Clinic. More often, people who develop rashes and other irritations from clothes are reacting to dyes, fabric softeners and finishers that can include formaldehyde. "Washing new clothes a couple of times before wearing can reduce that," Dr. Sood says.
Kid's clothes with zipper
Kids' clothes: Despite years of regulation making children's clothes safer, a few babies and even older children still strangle on drawstrings or get them caught in playground equipment. Skin can get caught in zippers, which are not recommended for children's clothing.

Lately, pediatricians have been warning of another issue: sock-line hyperpigmentation, raised reddish welts that can appear around ankles from socks with tight elastic. The marks are harmless but can last for years, doctors warn, and can also occur around wrists with tight mittens.

Super high heels. Source: dailymail.co.uk

Shoes: Heels higher than two inches have been linked to bunions, hammer toes, stress fractures and ankle sprains. Other ailments include "pump bumps" (bony protrusions on the back of heels), Morton's neuroma (an injury to the nerve between the toes) and Freiberg infraction (in which some foot bones die due to lack of circulation.) After years of wearing high heels, some fashionistas find that their Achilles tendons shorten, making flat shoes uncomfortable.

And flats can cause problems too, especially those with thin, unsupportive soles. In fact, any shoes without arch support can lead to plantar fasciitis, an inflammation in the band of tissue that runs along the bottom of the foot.

Flip-flops are even worse, according to the American Podiatric Medical Association. Researchers at Auburn University videotaped 39 volunteers and noticed they had to clench their toes to keep them on, leading to foot fatigue, sore calf muscles and an altered gait, which could cause long-term ankle and hip problems.
J Lo, Hillary Duff and Leighton Meester in Uggs. Source: whataretheywearing.com
 Think winter footwear is safer? Those popular fleece-lined, flat-soled boots have some of the same issues. Plus, the lining can be a breeding ground for athlete's foot and nail fungus. "Yes, they absorb moisture, but the moisture has nowhere to go," says Jeffrey Benabio, a dermatologist with Kaiser Permanente in San Diego, Calif. He recommends wearing fleece boots only outdoors, with socks, for short periods, and letting them dry out in between.

Accessory to a Crime of Fashion
Katie Holmes and her big bag

Fashion accessories have their own health hazards. Heavy handbags worn on one shoulder can throw the back out of line, especially if they have long straps and slouchy construction, which allows contents to shift. The American Chiropractic Association recommends that women carry no more than 10% of their body weight in a bag.

Cheryl Cole's hair extensions. Source: headkandy.com
 Wearing hair extensions for long periods or changing them frequently can create bald spots. Tight headbands, ponytails and braids can cause headaches

Even minute amounts of nickel in rings, earrings, belt buckles, watch backs and jeans rivets can cause an itchy red rash on people who have nickel allergy, which can begin suddenly even in adulthood.

Trapped soap and moisture can cause a rash under any kind of ring, but it tends to happen particularly with channel-set rings, with open spaces underneath stone settings.

Tattoo and body piercing. Source: bodypiercing-tattoos.blogspot.com

About 20% of body piercings develop a bacterial infection, according to a review by Northwestern University dermatologists published in the American Journal of Clinical Dermatology this month. 

References: "Tight Ties, Killer Heels: Clothes Make the Fashion Victims" Wall Street Journal Feb 2012

Friday, 16 March 2012

No sex? Have some booze.

Sex-starved fruit flies turn to drink


Drosophila SEM
Male fruit flies that have been rejected by females drink significantly more alcohol than those that have mated freely, scientists say.

In an article in Science, researchers suggest that alcohol stimulates the flies' brains as a "reward" in a similar way to sexual conquest.

The work points to a brain chemical called neuropeptide F, which seems to be regulated by the flies' behaviour.

Human brains have a similar chemical, which may react in a similar way. The connection between alcohol and this chemical, which in humans is known as neuropeptide Y, has already been noted in studies involving hard-drinking mice.

The new work explores the link between such reward-seeking and the study of social interactions, said the lead author of the report Galit Shohat-Ophir, now of the Howard Hughes Medical Institute in Virginia, US.

"It is thought that reward systems evolved to reinforce behaviours that are important for the survival of both individuals and species, like food consumption and mating," Dr Shohat-Ophir told BBC News.

"Drugs of abuse kind of hijack the same neural pathways used by natural rewards, so we wanted to use alcohol - which is an extreme example of a compound that can affect the reward system - to get into the mechanism of what makes social interaction rewarding for animals."

'Control system' Working in the laboratory of Ulrike Heberlein at the University of California, San Francisco, Dr Shohat-Ophir and colleagues subjected a number of flies to a wide variety of fates.

In one set of experiments, male flies were put in a box with five virgin females, which were receptive to the males' advances. In another, males were locked up with females that had already mated and which thus roundly rejected the males' attempts at sex.

Offered either their normal food slurry or a version charged with 15% alcohol, the mated males avoided the alcohol, whereas the sexually deprived males went on a comparative bender.

The team then went on a hunt for a chemical that could tie the two parts of this story together, hitting on neuropeptide F (NPF).
Neuropeptide Y 
 In mammals, the "rewarding" brain chemical is called neuropeptide Y
They found that the heavy-drinking rejected males had a lowered level of the chemical, and sated, mated males had an elevated level.

"What we think is that these NPF levels are some kind of 'molecular signature' to the experience," Dr Shohat-Ophir explained.

To show that the NPF is actually responsible for the change rather than just associated with it, the researchers actively manipulated just how much NPF was in the flies' brains.

Those with depressed levels acted like the rejected males, and those with elevated levels behaved like the mated males.

"What this leads us to think is that the fly brain - and presumably also other animals' and human brains - have some kind of a system to control their level of internal reward, that once the internal reward level is down-regulated it will be followed by behaviour that will restore it back," Dr Shohat-Ophir said.
It is tempting, given that humans share a similar brain chemical, to imagine that NPF drives human behaviour as well.

However, in an accompanying article in Science, Troy Zars of the University of Missouri wrote that "anthropomorphising the results from flies is difficult to suppress, but the relevance to human behaviour is obviously not yet established".
Nevertheless, he suggested that the work linked "a rewarding social interaction with a lasting change in behaviour".

"Identifying the NPF system as critical in this linkage offers exciting prospects for determining the molecular and genetic mechanisms of reward and could potentially influence our understanding of the mechanisms of drugs of abuse."

Sunday, 26 February 2012

Unlimited human eggs for fertility treatment

With the ability to produce "unlimited supply" of human eggs from stem cells, looks like I can put aside the regret of not freezing my eyes/ovary when I was younger... :D


Unlimited human eggs 'potential' for fertility treatment

Egg  
Researchers say stem cells in ovaries may one day improve fertility treatment

It may be possible to one day create an "unlimited" supply of human eggs to aid fertility treatment, US doctors say.

Researchers have shown it is possible to find stem cells in adult women which spontaneously produced new eggs in the laboratory.

Further experiments on mice showed such eggs could be fertilised, according to a study in the journal Nature Medicine.

One British expert said the study re-wrote the rule book with "exciting possibilities" for improving fertility.
The long-established theory is that women are born with all the eggs they will ever have. Lead researcher Dr Jonathan Tilly, from Massachusetts General Hospital, said this study, a follow up to one on mice in 2004, disproves that.

His team has reported finding and isolating the stem cells which go on to produce eggs in the ovaries of reproductive age women. It was done by searching for a protein, DDX4, which was unique to the surface of the stem cells. This allowed researchers to fish out the right cells.
When grown in the laboratory, the cells "spontaneously generated" immature eggs - or oocytes, which looked and acted like oocytes in the body.
The cells were "matured" when surrounded by living human ovarian tissue, which had been grafted inside mice.

There are tight legal and ethical restrictions on research on human eggs. The same experiments repeated using stem cells taken from mice showed the eggs could be fertilised with sperm and produced embryos. 

'Unprecedented' Dr Tilly said: "The primary objective of the current study was to prove that oocyte-producing stem cells do in fact exist in the ovaries of women during reproductive life, which we feel this study demonstrates very clearly.
"The discovery of oocyte precursor cells in adult human ovaries, coupled with the fact that these cells share the same characteristic features of their mouse counterparts that produce fully functional eggs, opens the door for development of unprecedented technologies to overcome infertility in women and perhaps even delay the timing of ovarian failure."

He told Nature: "These cells, when maintained outside of the body, are more than happy to make cells on their own and if we can guide that process I think it opens up the chance that sometime in the future we might get to the point of having an unlimited source of human eggs."

Dr Allan Pacey, a fertility expert at the University of Sheffield, said: "This is a nice study which shows quite convincingly that women's ovaries contain stem cells that can divide and make eggs.

"Not only does this re-write the rule book, it opens up a number of exciting possibilities for preserving the fertility of women undergoing treatment for cancer, or just maybe for women who are suffering infertility by extracting these cells and making her new eggs in the lab."

'Potential landmark' Stuart Lavery, a consultant gynaecologist and director of IVF at Hammersmith Hospital, said the findings were "extremely significant" and "a potentially landmark piece of research".

He told the BBC: "If this research is confirmed it may overturn one of the great asymmetries of reproductive biology - that a woman's reproductive pool of gametes may be renewable, just like a man's."

While cautioning that the cells were "some way" from any clinical use, Mr Lavery said they had potential, "particularly in young women facing sterilising treatment such as chemotherapy".